SKU LUM-TA1-5 · C₁₂₉H₂₁₅N₃₃O₅₅ · 3108.31 g/mol · CAS 62304-98-7
A 28-residue acetylated peptide originally isolated from thymic extracts. Studied as a modulator of cell-mediated immunity and dendritic-cell function.
Purity (HPLC)
≥ 99.18%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$90CAD/ 10 mg vial
In stock · Lot LM-2670
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years
Overview
Thymosin Alpha-1 is a 28-residue N-terminally acetylated peptide originally purified from thymic extracts and now manufactured by solid-phase synthesis. It is investigated for its effects on T-cell maturation, dendritic-cell activation, and Toll-like-receptor signaling.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our lab.
Research applications
T-cell differentiation and CD4/CD8 phenotyping, dendritic-cell activation and IFN-γ secretion assays, TLR2/TLR9 modulation studies, and in-vitro antiviral screening models.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Molecular formula
C₁₂₉H₂₁₅N₃₃O₅₅
Molecular weight
3108.31 g/mol
CAS number
62304-98-7
Length
28 residues
Quality
Test
Specification
HPLC purity
99.20%
Mass confirmation
ESI-MS within 0.5 Da
Net peptide content
≥ 80% by AAA
Endotoxin
< 0.5 EU/mg (LAL)
Bioburden
< 10 CFU/g
Residual TFA
< 1.0%
Lot LM-2670
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.20% main peak
ESI-MS (positive)
3108.3 Da (theor. 3108.31)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Goldstein AL, Goldstein AL. From lab to bedside: emerging clinical applications of thymosin alpha 1. Expert Opin Biol Ther. 2009;9(5):593–608.
Romani L et al. Thymosin alpha 1 activates dendritic cells. Blood. 2004;103(11):4232–4239.
King R, Tuthill C. Immune modulation with thymosin alpha 1 treatment. Vitam Horm. 2016;102:151–178.
Thymosin Alpha 1 is an immune-modulating peptide, classified within the innate + adaptive immunity pathway. Structurally it is a 28-residue acetylated peptide. Thymosin Alpha-1 (Tα1) is a 28-residue acetylated peptide first isolated by Goldstein et al. (1977) from bovine thymus. It modulates dendritic-cell maturation and T-cell function.
In an in-vitro setting, Thymosin Alpha 1 interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable until reconstituted.
Common research applications
In-vitro receptor-binding and dose-response screens against the innate + adaptive immunity target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Thymosin Alpha 1's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.
Storage & handling
Thymosin Alpha 1 arrives lyophilized in Canada Post (~4 days). On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.
References
Goldstein AL et al. Proc Natl Acad Sci USA. 1977;74(2):725-9.
Romani L et al. Ann N Y Acad Sci. 2010;1194:191-8.
Costantini C et al. Front Immunol. 2019;10:873.
For laboratory research only. Thymosin Alpha 1 is sold strictly as an in-vitro reference standard. Sold as an in-vitro reference standard, not as a Health Canada or FDA-approved therapeutic.
