> KPV 10 mg · Lumera Labs
For laboratory research use only. Not for human consumption. Free cold-chain shipping over $90 CAD · Ships from Kelowna, BC
Free cold-chain shipping over $200 CAD · Ships from Kelowna, BC
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KPV 10 mg vial
4.9 · 54 researcher reviews
Healing · Anti-inflammatory tripeptide

KPV

SKU LUM-KPV-50 · C₁₉H₃₅N₅O₄ · 397.51 g/mol · CAS 78568-30-2

A C-terminal tripeptide fragment of α-MSH studied for anti-inflammatory pathways through MC1R and intracellular targets.

Purity (HPLC)
≥ 99.05%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$90CAD / 10 mg vial
In stock · Lot 26-A031
Qty
Bulk 10+: $24 / vial
Add $200 for free cold-chain shipping
  • HPLC + MS verified per lot
  • Cold-chain to your door
  • COA bundled with shipment
  • Lot retains kept 5 years

Overview

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of α-MSH. It retains potent anti-inflammatory activity attributed to MC1R signaling and to intracellular interactions with NF-κB pathways. It is investigated as a research tool for inflammation pathway dissection.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

NF-κB pathway inhibition assays, in-vitro colitis and dermatitis models, and comparative anti-inflammatory pharmacology versus α-MSH.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

ParameterValue
SequenceLys-Pro-Val
Molecular formulaC₁₉H₃₅N₅O₄
Molecular weight397.51 g/mol
CAS number78568-30-2
Length3 residues

Quality

TestSpecification
HPLC purity≥ 99.0% (lot LM-2652: 99.31%)
Mass confirmationESI-MS within 0.5 Da
Net peptide content≥ 80% by AAA
Endotoxin< 0.5 EU/mg (LAL)
Bioburden< 10 CFU/g
Residual TFA< 1.0%

Lot LM-2652

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

MethodResult
RP-HPLC at 220 nm99.31% main peak
ESI-MS (positive)397.5 Da (theor. 397.51)
Amino acid analysis82.1% net peptide
LAL endotoxin< 0.05 EU/mg
Karl Fischer (water)2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Catania A et al. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840–1853.

Kannengiesser K et al. Melanocortin-derived tripeptide KPV ameliorates colitis. Inflamm Bowel Dis. 2008;14(3):324–331.

Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of α-MSH. FASEB J. 1989;3(11):2282–2284.

Citing this material

KPV reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-KPV-50, Lot 26-A031.

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Why Lumera

  • Janoshik Analytical HPLC ≥ 99.05% on this lot
  • LC-MS identity confirmed before release
  • LAL endotoxin below detection limit
  • Cold-chain shipped −20°C from Kelowna, BC
Background research

What the literature says about Kpv.

Mechanism

Kpv is an anti-inflammatory tripeptide, classified within the MC1R signaling pathway. Structurally it is a Lys-Pro-Val C-terminal α-MSH fragment. KPV is the C-terminal tripeptide fragment of α-melanocyte-stimulating hormone (α-MSH). Brzoska et al. (2008) reviewed its anti-inflammatory activity through MC1R-dependent and -independent pathways.

In an in-vitro setting, Kpv interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable at −20 °C until reconstituted.

Common research applications

  • In-vitro receptor-binding and dose-response screens against the MC1R signaling target panel.
  • Comparative pharmacology against related class members and previously published reference standards.
  • Time-course studies leveraging Kpv's known stability profile.
  • Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.

Storage & handling

Kpv arrives lyophilized at −20 °C in cold-chain insulated packaging. On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.

References

  1. Brzoska T et al. Endocr Rev. 2008;29(5):581-602.
  2. Cutuli M et al. J Leukoc Biol. 2000;67(2):233-9.
  3. Mandrika I et al. Biochem Biophys Res Commun. 2001;286(5):1017-21.

For laboratory research only. Kpv is sold strictly as an in-vitro reference standard. It is not approved for human or veterinary use by Health Canada or the FDA.

$90 CAD