SKU LUM-KPV-50 · C₁₉H₃₅N₅O₄ · 397.51 g/mol · CAS 78568-30-2
A C-terminal tripeptide fragment of α-MSH studied for anti-inflammatory pathways through MC1R and intracellular targets.
Purity (HPLC)
≥ 99.05%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$65CAD/ 10 mg vial
In stock · Lot LM-2701
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years
Overview
KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of α-MSH. It retains potent anti-inflammatory activity attributed to MC1R signaling and to intracellular interactions with NF-κB pathways. It is investigated as a research tool for inflammation pathway dissection.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our lab.
Research applications
NF-κB pathway inhibition assays, in-vitro colitis and dermatitis models, and comparative anti-inflammatory pharmacology versus α-MSH.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
Lys-Pro-Val
Molecular formula
C₁₉H₃₅N₅O₄
Molecular weight
397.51 g/mol
CAS number
78568-30-2
Length
3 residues
Quality
Test
Specification
HPLC purity
99.462%
Mass confirmation
ESI-MS within 0.5 Da
Net peptide content
≥ 80% by AAA
Endotoxin
< 0.5 EU/mg (LAL)
Bioburden
< 10 CFU/g
Residual TFA
< 1.0%
Lot LM-2701
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.31% main peak
ESI-MS (positive)
397.5 Da (theor. 397.51)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Catania A et al. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840–1853.
Kannengiesser K et al. Melanocortin-derived tripeptide KPV ameliorates colitis. Inflamm Bowel Dis. 2008;14(3):324–331.
Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of α-MSH. FASEB J. 1989;3(11):2282–2284.
Kpv is an anti-inflammatory tripeptide, classified within the MC1R signaling pathway. Structurally it is a Lys-Pro-Val C-terminal α-MSH fragment. KPV is the C-terminal tripeptide fragment of α-melanocyte-stimulating hormone (α-MSH). Brzoska et al. (2008) reviewed its anti-inflammatory activity through MC1R-dependent and -independent pathways.
In an in-vitro setting, Kpv interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable until reconstituted.
Common research applications
In-vitro receptor-binding and dose-response screens against the MC1R signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Kpv's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.
Storage & handling
Kpv arrives lyophilized in Canada Post (~4 days). On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.
References
Brzoska T et al. Endocr Rev. 2008;29(5):581-602.
Cutuli M et al. J Leukoc Biol. 2000;67(2):233-9.
Mandrika I et al. Biochem Biophys Res Commun. 2001;286(5):1017-21.
For laboratory research only. Kpv is sold strictly as an in-vitro reference standard. Sold as an in-vitro reference standard, not as a Health Canada or FDA-approved therapeutic.
