Is Retatrutide from Lumera Labs HPLC verified?

Yes. Every Retatrutide lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Testides before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

How is Retatrutide shipped?

Retatrutide is lyophilized at synthesis, sealed under nitrogen, and shipped across Canada via Canada Post Xpresspost in ~4 days. Free shipping over $300 CAD. ~4 days transit Canada-wide.

Where can I see the COA for Retatrutide?

The lot-specific Certificate of Analysis is posted on our Lab Results page (/lab-results/) and attached to your order in your account (/account/).

What does HPLC-verified mean?

Every lot we sell is tested by an independent third-party lab (Testides) using High-Performance Liquid Chromatography. The Certificate of Analysis reports HPLC-UV purity and peptide content by mass. We post the COA next to each product so you can verify before ordering.

How is it shipped within Canada?

Canada Post Xpresspost. Most provinces arrive in ~4 days from dispatch. Free shipping on Canadian orders over $300; otherwise a flat $25 shipping fee applies.

Is this for human or animal use?

All Lumera products are supplied strictly for laboratory research use only, in-vitro reference standards. By ordering you confirm you have read and accept our Research Use Declaration.

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Home / Catalog / Metabolic / Retatrutide 5 mg

Tri-agonist · Metabolic Axis

Retatrutide

Name: Retatrutide
Brand: Lumera Labs
SKU: LUM-RETA-10
Availability: InStock

SKU LUM-RETA-10 · C₂₂₁H₃₄₃N₅₃O₆₅ · 4731.42 g/mol · CAS 2381089-83-2

A triple agonist of GLP-1, GIP, and glucagon receptors, supplied lyophilized for in-vitro tri-receptor activation studies.

Read the Retatrutide research monograph →

Purity (HPLC): ≥ 99.96%
Peptide content (tested 10 mg lot vial): 11.27 mg · 113% of label
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$60CAD / 5 mg vial

In stock · Lot LM-2777

Qty

Add $300 for Free shipping

Testides Lab

Lab Result: Retatrutide 10mg (Lot LM-2777)

COAs are issued per production lot. This lot's tested vial: 10 mg.

Avg. Purity99.96%

Avg. Mass11.27 mg

Result DateJuly 2, 2026

Date AddedJuly 4, 2026

View full report →

HPLC-UV verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years

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Overview

Retatrutide (LY3437943) is a 39-residue synthetic peptide engineered to activate all three incretin/glucagon-axis receptors: GLP-1R, GIPR, and GCGR. The C20 fatty-diacid attachment confers albumin binding and an extended functional half-life. The combined receptor activity drives a distinct downstream signaling profile relative to dual or mono-agonists.

Each vial is lyophilized from acetate buffer at pH 4.0, sealed under nitrogen, and shipped ~4 days from our lab.

Research applications

Triple-receptor (GLP-1R/GIPR/GCGR) activation studies, comparative cAMP and β-arrestin recruitment screens versus tirzepatide and semaglutide, in-vivo metabolic phenotype models, and lipolytic-pathway investigations. Compatible with HEK293 and CHO cells expressing the relevant receptors.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	Synthetic 39-residue triagonist analog with γGlu-C20 lipid modification
Molecular formula	C₂₂₁H₃₄₃N₅₃O₆₅
Molecular weight	4731.42 g/mol
CAS number	2381089-83-2
Length	39 residues

Quality

Test	Specification
HPLC purity	99.96%
Peptide content (HPLC-UV)	11.27 mg · 113% of label
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2777

Manufactured 02 May 2026 · Released 02 Jul 2026 · Independently tested by Testides (report LUME-RETA-10-061626). Retain samples held under storage spec for five years from release date.

View COA (Testides) →

Verification

Method	Result
RP-HPLC-UV at 214 nm	99.96% main peak
Peptide content (HPLC-UV)	11.27 mg (113% of 10 mg)
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0-2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2-8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Coskun T et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. 2022;34(9):1234-1247.

Jastreboff AM et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity. N Engl J Med. 2023;389(6):514-526.

Rosenstock J et al. Retatrutide in adults with type 2 diabetes. Lancet. 2023;402(10401):529-544.

Citing this material

Retatrutide reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-RETA-10, Lot LM-2777.

Retatrutide

Lab Result: Retatrutide 10mg (Lot LM-2777)

Overview

Research applications

Identity

Quality

Lot LM-2777

Verification

Reconstitution

Storage after reconstitution

Selected references

Citing this material

Why Lumera

What the literature says about Retatrutide.

Mechanism

Common research applications

Storage & handling

References

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