SKU LUM-SEMAX-30 · C₃₉H₅₄N₁₀O₁₀S · 854.97 g/mol · CAS 80714-61-0
A heptapeptide analog of ACTH(4-10) with neuroprotective and BDNF-modulating activity. Investigated as a research tool for cognitive pharmacology.
Purity (HPLC)
≥ 99.2%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$50CAD/ 10 mg vial
In stock · Lot LM-2730
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years
Overview
Semax is a synthetic heptapeptide analog of ACTH(4-7) extended by a Pro-Gly-Pro tripeptide. Unlike full ACTH, it does not stimulate corticosteroid release; instead, it modulates BDNF expression, NGF/TrkA signaling, and dopaminergic/serotonergic activity in the CNS.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our lab.
Research applications
BDNF/NGF expression assays in cortical neurons, behavioral pharmacology in rodent learning/memory paradigms, and TrkA/TrkB signaling investigations.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Molecular formula
C₃₉H₅₄N₁₀O₁₀S
Molecular weight
854.97 g/mol
CAS number
80714-61-0
Length
7 residues
Quality
Test
Specification
HPLC purity
99.922%
Mass confirmation
ESI-MS within 0.5 Da
Net peptide content
≥ 80% by AAA
Endotoxin
< 0.5 EU/mg (LAL)
Bioburden
< 10 CFU/g
Residual TFA
< 1.0%
Lot LM-2730
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.22% main peak
ESI-MS (positive)
855.0 Da (theor. 854.97)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Levitskaya NG et al. Effects of semax and its C-terminal fragment Pro-Gly-Pro on the behavior of white rats. Neurosci Behav Physiol. 2002;32(4):355–360.
Dolotov OV et al. Semax, an analog of ACTH(4-10), and its des-glycine analog: synthesis, biological activity. J Mol Neurosci. 2006;28(2):133–141.
Andreeva LA et al. Synthetic heptapeptide Semax. Russ J Bioorg Chem. 2010;36(4):457–467.
Semax is a synthetic ACTH 4-7 analog, classified within the neurotrophic signaling pathway. Structurally it is a Met-Glu-His-Phe-Pro-Gly-Pro heptapeptide. Semax is a synthetic heptapeptide analog of ACTH(4-10) developed by Russian neuroscientists. Levitskaya et al. (2002) reviewed its nootropic and neuroprotective effects in animal models.
In an in-vitro setting, Semax interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable until reconstituted.
Common research applications
In-vitro receptor-binding and dose-response screens against the neurotrophic signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Semax's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.
Storage & handling
Semax arrives lyophilized in Canada Post (~4 days). On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.
References
Levitskaya NG et al. Neurosci Behav Physiol. 2002;32(4):355-9.
Dolotov OV et al. Brain Res. 2006;1117(1):54-60.
Kost NV et al. Peptides. 2002;23(11):1953-60.
For laboratory research only. Semax is sold strictly as an in-vitro reference standard. Sold as an in-vitro reference standard, not as a Health Canada or FDA-approved therapeutic.
