Is DSIP from Lumera Labs HPLC verified?

Yes. Every DSIP lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

Is DSIP sold for human use?

No. DSIP is sold strictly as a laboratory reference standard for in-vitro research. It is not approved by Health Canada or the FDA for human use. Every order requires a research-use declaration.

DSIP is lyophilized at synthesis, sealed under nitrogen, and shipped from Kelowna, BC at -20 C through cold-chain insulated packaging via Canada Post Xpresspost. Free shipping over $200 CAD. 24-48h transit Canada-wide.

Where can I see the COA for DSIP?

Each shipment includes a lot-specific Certificate of Analysis. The current lot's COA is also published at https://lumerapeptide.com/lab-results/ and can be cross-referenced by the batch number printed on each vial.

Home / Catalog / Neuro / DSIP 10 mg

4.7 · 332 researcher reviews

Cognitive · Sleep-related peptide

DSIP

SKU LUM-DSIP-5 · C₃₅H₄₈N₁₀O₁₅ · 848.83 g/mol · CAS 62568-57-4

Delta-sleep-inducing peptide — a 9-residue endogenous neuropeptide isolated from cerebral venous blood during slow-wave sleep.

Purity (HPLC): ≥ 99.05%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$70CAD / 10 mg vial

In stock · Lot 26-A031

Qty

Bulk 10+: $24 / vial

Add $200 for free cold-chain shipping

HPLC + MS verified per lot
Cold-chain to your door
COA bundled with shipment
Lot retains kept 5 years

Overview

Delta-Sleep-Inducing Peptide (DSIP) is a 9-residue endogenous neuropeptide originally isolated from cerebral venous blood of sleeping rabbits. Despite the name, its primary research interest extends beyond sleep architecture into stress-response, opioid-receptor modulation, and circadian-axis pharmacology.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

Slow-wave-sleep EEG modulation studies, opioid-receptor binding assays, ACTH/cortisol stress-response investigations, and circadian-clock gene-expression studies.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular formula	C₃₅H₄₈N₁₀O₁₅
Molecular weight	848.83 g/mol
CAS number	62568-57-4
Length	9 residues

Quality

Test	Specification
HPLC purity	≥ 99.0% (lot LM-2662: 99.06%)
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2662

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.06% main peak
ESI-MS (positive)	848.8 Da (theor. 848.83)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977;74(3):1282–1286.

Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83–93.

Khvatova EM et al. DSIP and stress: actions on neurochemical and metabolic parameters. Stress. 2003;6(1):79–86.