SKU LUM-MOTSC-10 · C₁₀₀H₁₅₈N₂₆O₂₂S · 2174.55 g/mol · CAS 1627580-64-6
A 16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene. Studied for AMPK activation and metabolic homeostasis.
Purity (HPLC)
≥ 99.16%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$120CAD/ 40 mg vial
In stock · Lot 26-A031
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days typical to your door
COA bundled with shipment
Lot retains kept 5 years
Overview
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-residue peptide encoded within the mitochondrial genome and translated in the cytoplasm. It activates AMPK, modulates folate–methionine cycling, and is investigated for its roles in glucose homeostasis, exercise capacity, and longevity pathways.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days typical from our lab.
Research applications
AMPK-activation screens (Thr172 phosphorylation), 5-methyl-THF/SAM metabolomics, in-vitro glucose-uptake assays in skeletal myoblasts, and comparative mitochondrial-derived peptide pharmacology.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
MRWQEMGYIFYPRKLR
Molecular formula
C₁₀₀H₁₅₈N₂₆O₂₂S
Molecular weight
2174.55 g/mol
CAS number
1627580-64-6
Length
16 residues
Quality
Test
Specification
HPLC purity
99.443%
Mass confirmation
ESI-MS within 0.5 Da
Net peptide content
≥ 80% by AAA
Endotoxin
< 0.5 EU/mg (LAL)
Bioburden
< 10 CFU/g
Residual TFA
< 1.0%
Lot LM-2774
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.13% main peak
ESI-MS (positive)
2174.6 Da (theor. 2174.55)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015;21(3):443–454.
Reynolds JC et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.
Kim KH et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression. Cell Metab. 2018;28(3):516–524.
Shipped in ~4 days typical via Xpresspost from Canada
Background research
What the literature says about Mots C.
Mechanism
Mots C is a mitochondrial-derived peptide, classified within the mitochondrial-nuclear signaling pathway. Structurally it is a 16-residue MDP from MT-RNR1. MOTS-c is a 16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene. Lee et al. (2015) demonstrated its role in metabolic homeostasis through AMPK activation.
In an in-vitro setting, Mots C interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable until reconstituted.
Common research applications
In-vitro receptor-binding and dose-response screens against the mitochondrial-nuclear signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Mots C's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.
Storage & handling
Mots C arrives lyophilized in Canada Post (~4 days typical). On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.
References
Lee C et al. Cell Metab. 2015;21(3):443-54.
Reynolds JC et al. Nat Commun. 2021;12:470.
Yen K et al. Trends Endocrinol Metab. 2013;24(5):222-8.
For laboratory research only. Mots C is sold strictly as an in-vitro reference standard. Sold as an in-vitro reference standard, not as a Health Canada or FDA-approved therapeutic.
