Hexarelin is a synthetic hexapeptide that activates both the GHS-R1a (ghrelin receptor) and CD36, distinguishing it from more selective ghrelin-receptor agonists. The dual mechanism is investigated for cardiovascular research alongside its primary GH-releasing activity.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our lab.
Research applications
GHS-R1a and CD36 binding-affinity assays, pituitary GH-release potentiation studies, cardiomyocyte protection screens, and comparative ghrelin-receptor pharmacology.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂
Molecular formula
C₄₇H₅₈N₁₂O₆
Molecular weight
887.04 g/mol
CAS number
140703-51-1
Length
6 residues
Quality
Test
Specification
HPLC purity
99.12%
Certificate of Analysis
The lot-specific COA for this product is available on request. Email support@lumerapeptide.com with your batch number and we will send it.
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0-2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2-8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Locatelli V et al. Effect of GH-releasing hexapeptide (GHRP-6) on GH secretion. J Endocrinol. 1994;142(1):65-71.
Bodart V et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res. 2002;90(8):844-849.
Mao Y et al. Hexarelin treatment in male ghrelin knockout mice. J Endocrinol. 2014;220(2):217-227.
