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A synthetic hexapeptide growth-hormone secretagogue and ghrelin-receptor agonist. Studied for cardiovascular and pituitary-axis pharmacology.
Hexarelin is a synthetic hexapeptide that activates both the GHS-R1a (ghrelin receptor) and CD36, distinguishing it from more selective ghrelin-receptor agonists. The dual mechanism is investigated for cardiovascular research alongside its primary GH-releasing activity.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.
GHS-R1a and CD36 binding-affinity assays, pituitary GH-release potentiation studies, cardiomyocyte protection screens, and comparative ghrelin-receptor pharmacology.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
| Parameter | Value |
|---|---|
| Sequence | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
| Molecular formula | C₄₇H₅₈N₁₂O₆ |
| Molecular weight | 887.04 g/mol |
| CAS number | 140703-51-1 |
| Length | 6 residues |
| Test | Specification |
|---|---|
| HPLC purity | ≥ 99.0% (lot LM-2647: 99.12%) |
| Mass confirmation | ESI-MS within 0.5 Da |
| Net peptide content | ≥ 80% by AAA |
| Endotoxin | < 0.5 EU/mg (LAL) |
| Bioburden | < 10 CFU/g |
| Residual TFA | < 1.0% |
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.
| Method | Result |
|---|---|
| RP-HPLC at 220 nm | 99.12% main peak |
| ESI-MS (positive) | 887.0 Da (theor. 887.04) |
| Amino acid analysis | 82.1% net peptide |
| LAL endotoxin | < 0.05 EU/mg |
| Karl Fischer (water) | 2.8% w/w |
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Locatelli V et al. Effect of GH-releasing hexapeptide (GHRP-6) on GH secretion. J Endocrinol. 1994;142(1):65–71.
Bodart V et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res. 2002;90(8):844–849.
Mao Y et al. Hexarelin treatment in male ghrelin knockout mice. J Endocrinol. 2014;220(2):217–227.
Hexarelin reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-HEX-2, Lot 26-A031.