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A synthetic 44-residue analog of human growth-hormone-releasing hormone with N-terminal trans-3-hexenoyl modification for protease resistance.
Tesamorelin is a synthetic analog of human GHRH(1-44) with a trans-3-hexenoyl group attached to the N-terminal tyrosine. The lipid modification confers resistance to dipeptidyl peptidase-IV cleavage, extending its functional half-life relative to native GHRH.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.
GHRH-receptor activation potency assays, comparative DPP-IV resistance screens, pituitary GH-secretion studies, and visceral-adipose-tissue lipolysis models.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
| Parameter | Value |
|---|---|
| Sequence | trans-3-hexenoyl-Tyr¹-hGHRH(1-44) |
| Molecular formula | C₂₂₁H₃₆₆N₇₂O₆₇S |
| Molecular weight | 5135.86 g/mol |
| CAS number | 901758-09-6 |
| Length | 44 residues |
| Test | Specification |
|---|---|
| HPLC purity | ≥ 99.0% (lot LM-2642: 99.06%) |
| Mass confirmation | ESI-MS within 0.5 Da |
| Net peptide content | ≥ 80% by AAA |
| Endotoxin | < 0.5 EU/mg (LAL) |
| Bioburden | < 10 CFU/g |
| Residual TFA | < 1.0% |
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.
| Method | Result |
|---|---|
| RP-HPLC at 220 nm | 99.06% main peak |
| ESI-MS (positive) | 5135.9 Da (theor. 5135.86) |
| Amino acid analysis | 82.1% net peptide |
| LAL endotoxin | < 0.05 EU/mg |
| Karl Fischer (water) | 2.8% w/w |
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Falutz J et al. Effects of tesamorelin on visceral fat in HIV lipodystrophy. N Engl J Med. 2007;357(23):2359–2370.
Stanley TL et al. Effects of tesamorelin on hepatic fat. Lancet HIV. 2019;6(12):e821–e830.
Ferdinandi ES et al. Pharmacokinetics of tesamorelin. Clin Pharmacokinet. 2007;46(4):331–343.
Tesamorelin reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-TESA-2, Lot 26-A031.