Is Semaglutide from Lumera Labs HPLC verified?

Yes. Every Semaglutide lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

How is Semaglutide shipped?

Semaglutide is lyophilized at synthesis, sealed under nitrogen, and shipped across Canada via Canada Post Xpresspost in ~4 days. Free shipping over $300 CAD. ~4 days transit Canada-wide.

Where can I see the COA for Semaglutide?

Lot-specific Certificate of Analysis available on request — email lumeralabs@proton.me with the lot/batch number from your order confirmation and we'll send it for your records.

What does HPLC-verified mean?

Every lot we sell is tested by an independent third-party lab (Janoshik Analytical) using High-Performance Liquid Chromatography. The Certificate of Analysis reports purity, peptide content by mass, and identity. We post the COA next to each product so you can verify before ordering.

How is it shipped within Canada?

Canada Post Xpresspost. Most provinces arrive in ~4 days from dispatch. Free shipping on Canadian orders over $300; otherwise a flat $25 shipping fee applies.

Is this for human or animal use?

All Lumera products are supplied strictly for laboratory research use only — in-vitro reference standards. By ordering you confirm you have read and accept our Research Use Declaration.

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Home / Catalog / Metabolic / Semaglutide 10 mg

GLP-1 · Metabolic Axis

Semaglutide

SKU LUM-SEMA-5 · C₁₈₇H₂₉₁N₄₅O₅₉ · 4113.58 g/mol · CAS 910463-68-2

A 31-residue GLP-1 receptor agonist with a fatty-acid side chain at Lys26 for albumin-mediated half-life extension. Lyophilized from acetate buffer; reconstitute with bacteriostatic water for in-vitro receptor assays.

Purity (HPLC): ≥ 99.41%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$85CAD / 10 mg vial

In stock · Lot LM-2602

Add $300 for Free shipping

HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years

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Overview

Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist used as a reference standard in metabolic and incretin-axis research. The C18 fatty diacid attached at Lys26 binds serum albumin reversibly, conferring a 165-hour effective half-life in mammalian models and reducing assay-to-assay drift in time-course studies.

Each vial is lyophilized from acetate-buffered solution at pH 4.0, sealed under nitrogen, and held through ship. Insulated tracked shipping is maintained from our lab to your bench.

Research applications

In-vitro GLP-1R potency assays, β-arrestin recruitment screens, comparative pharmacokinetics versus exenatide and liraglutide, and structural studies of receptor-bound conformations. Compatible with HEK293, CHO, and INS-1E cell lines.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Molecular formula	C₁₈₇H₂₉₁N₄₅O₅₉
Molecular weight	4113.58 g/mol
CAS number	910463-68-2
Sequence length	31 residues
Modification	γ-Glu-C18 diacid at Lys26

Quality

Test	Specification
HPLC purity	99.383%
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2602

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.41% main peak
ESI-MS (positive)	4113.6 Da (theor. 4113.58)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Knudsen LB, Lau J. The discovery and development of liraglutide and semaglutide. Front Endocrinol. 2019;10:155.

Lau J et al. Discovery of the once-weekly GLP-1 analogue semaglutide. J Med Chem. 2015;58(18):7370–80.

Citing this material

Semaglutide reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-SEMA-5, Lot LM-2602.

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Often paired in studies.

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Retatrutide

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Semaglutide

Overview

Research applications

Identity

Quality

Lot LM-2602

Verification

Reconstitution

Storage after reconstitution

Selected references

Citing this material

Often paired in studies.

Retatrutide

Why Lumera

What the literature says about Semaglutide.

Mechanism

Common research applications

Storage & handling

References

Compare this compound