SKU LUM-5A1MQ-50 · C₁₀H₁₂N₂ · 160.22 g/mol · CAS 57052-10-7
A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Studied for sirtuin and methionine-cycle pharmacology.
Purity (HPLC)
≥ 99.1%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$150CAD/ 50 mg vial
In stock · Lot LM-2691
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years
Overview
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that consumes SAM and nicotinamide to produce 1-methylnicotinamide. NNMT inhibition raises cellular nicotinamide and SAM, indirectly modulating sirtuin substrate availability and methylation potential.
Lumera supplies 5-Amino-1MQ as a lyophilized powder for in-vitro biochemistry use. Vials are sealed under nitrogen and shipped ~4 days from our lab.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.42% main peak
ESI-MS (positive)
160.2 Da (theor. 160.22)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Kannt A et al. A small molecule inhibitor of nicotinamide N-methyltransferase. J Med Chem. 2016;59(20):9390–9402.
Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase. Biochem Pharmacol. 2017;133:103–115.
Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340–353.
