5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that consumes SAM and nicotinamide to produce 1-methylnicotinamide. NNMT inhibition raises cellular nicotinamide and SAM, indirectly modulating sirtuin substrate availability and methylation potential.
Lumera supplies 5-Amino-1MQ as a lyophilized powder for in-vitro biochemistry use. Vials are sealed under nitrogen and shipped ~4 days from our lab.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0-2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2-8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Kannt A et al. A small molecule inhibitor of nicotinamide N-methyltransferase. J Med Chem. 2016;59(20):9390-9402.
Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase. Biochem Pharmacol. 2017;133:103-115.
Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340-353.
