Is 5-Amino-1MQ from Lumera Labs HPLC verified?

Yes. Every 5-Amino-1MQ lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

Is 5-Amino-1MQ sold for human use?

No. 5-Amino-1MQ is sold strictly as a laboratory reference standard for in-vitro research. It is not approved by Health Canada or the FDA for human use. Every order requires a research-use declaration.

How is 5-Amino-1MQ shipped?

5-Amino-1MQ is lyophilized at synthesis, sealed under nitrogen, and shipped from Kelowna, BC at -20 C through cold-chain insulated packaging via Canada Post Xpresspost. Free shipping over $200 CAD. 24-48h transit Canada-wide.

Where can I see the COA for 5-Amino-1MQ?

Each shipment includes a lot-specific Certificate of Analysis. The current lot's COA is also published at https://lumerapeptide.com/lab-results/ and can be cross-referenced by the batch number printed on each vial.

Home / Catalog / Metabolic / 5-Amino-1MQ 50 mg

4.7 · 118 researcher reviews

Longevity · Small-molecule NNMT inhibitor

5-Amino-1MQ

SKU LUM-5A1MQ-50 · C₁₀H₁₂N₂ · 160.22 g/mol · CAS 57052-10-7

A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Studied for sirtuin and methionine-cycle pharmacology.

Purity (HPLC): ≥ 99.1%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$70CAD / 50 mg vial

In stock · Lot 26-A031

Bulk 10+: $24 / vial

Add $200 for free cold-chain shipping

HPLC + MS verified per lot
Cold-chain to your door
COA bundled with shipment
Lot retains kept 5 years

Overview

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that consumes SAM and nicotinamide to produce 1-methylnicotinamide. NNMT inhibition raises cellular nicotinamide and SAM, indirectly modulating sirtuin substrate availability and methylation potential.

Lumera supplies 5-Amino-1MQ as a lyophilized powder for in-vitro biochemistry use. Vials are sealed under nitrogen and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

NNMT enzymatic inhibition assays, cellular SAM/methylation balance studies, sirtuin substrate-availability investigations, and adipocyte energy-expenditure models.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	5-amino-1-methylquinolinium (small-molecule heterocycle)
Molecular formula	C₁₀H₁₂N₂
Molecular weight	160.22 g/mol
CAS number	57052-10-7
Length	Small molecule (not a peptide)

Quality

Test	Specification
HPLC purity	≥ 99.0% (lot LM-2657: 99.42%)
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2657

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.42% main peak
ESI-MS (positive)	160.2 Da (theor. 160.22)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Kannt A et al. A small molecule inhibitor of nicotinamide N-methyltransferase. J Med Chem. 2016;59(20):9390–9402.

Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase. Biochem Pharmacol. 2017;133:103–115.

Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340–353.