> Kisspeptin-10 10 mg · Lumera Labs
For laboratory research use only. Not for human consumption. Free cold-chain shipping over $50 CAD · Ships from Kelowna, BC
Free cold-chain shipping over $200 CAD · Ships from Kelowna, BC
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Kisspeptin-10 10 mg vial
4.8 · 123 researcher reviews
Cognitive · Reproductive axis

Kisspeptin-10

SKU LUM-KP10-1 · C₆₃H₈₃N₁₇O₁₄ · 1302.45 g/mol · CAS 374675-21-5

A C-terminal decapeptide fragment of kisspeptin (KISS1) that activates the GPR54/KISS1R receptor. Investigated for hypothalamic-pituitary-gonadal axis signaling.

Purity (HPLC)
≥ 99.1%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$50CAD / 10 mg vial
In stock · Lot 26-A031
Qty
Bulk 10+: $24 / vial
Add $200 for free cold-chain shipping
  • HPLC + MS verified per lot
  • Cold-chain to your door
  • COA bundled with shipment
  • Lot retains kept 5 years

Overview

Kisspeptin-10 (KP-10) is the minimal C-terminal active fragment of the KISS1 gene product. It binds the G-protein-coupled receptor GPR54 (KISS1R) and stimulates GnRH neurons in the hypothalamus, driving downstream LH and FSH secretion.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

GPR54/KISS1R activation potency screens, GnRH-neuron Ca²⁺-mobilization assays, in-vitro hypothalamic explant studies, and reproductive-axis pharmacology.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

ParameterValue
SequenceYNWNSFGLRF-NH₂
Molecular formulaC₆₃H₈₃N₁₇O₁₄
Molecular weight1302.45 g/mol
CAS number374675-21-5
Length10 residues

Quality

TestSpecification
HPLC purity≥ 99.0% (lot LM-2641: 99.17%)
Mass confirmationESI-MS within 0.5 Da
Net peptide content≥ 80% by AAA
Endotoxin< 0.5 EU/mg (LAL)
Bioburden< 10 CFU/g
Residual TFA< 1.0%

Lot LM-2641

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

MethodResult
RP-HPLC at 220 nm99.17% main peak
ESI-MS (positive)1302.5 Da (theor. 1302.45)
Amino acid analysis82.1% net peptide
LAL endotoxin< 0.05 EU/mg
Karl Fischer (water)2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

de Roux N et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA. 2003;100(19):10972–10976.

Pinilla L et al. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev. 2012;92(3):1235–1316.

Skorupskaite K et al. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485–500.

Citing this material

Kisspeptin-10 reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-KP10-1, Lot 26-A031.

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Why Lumera

  • Janoshik Analytical HPLC ≥ 99.1% on this lot
  • LC-MS identity confirmed before release
  • LAL endotoxin below detection limit
  • Cold-chain shipped −20°C from Kelowna, BC
Background research

What the literature says about Kisspeptin 10.

Mechanism

Kisspeptin 10 is a reproductive endocrine reference standard, classified within the GPR54 signaling pathway. Structurally it is a decapeptide KISS1 fragment. Kisspeptin-10 is the active 10-residue C-terminal fragment of the KISS1 gene product. de Roux et al. (2003) and Seminara et al. (2003) identified its role as the master regulator of GnRH secretion.

In an in-vitro setting, Kisspeptin 10 interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable at −20 °C until reconstituted.

Common research applications

  • In-vitro receptor-binding and dose-response screens against the GPR54 signaling target panel.
  • Comparative pharmacology against related class members and previously published reference standards.
  • Time-course studies leveraging Kisspeptin 10's known stability profile.
  • Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.

Storage & handling

Kisspeptin 10 arrives lyophilized at −20 °C in cold-chain insulated packaging. On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.

References

  1. de Roux N et al. Proc Natl Acad Sci USA. 2003;100(19):10972-6.
  2. Seminara SB et al. N Engl J Med. 2003;349(17):1614-27.
  3. Skorupskaite K et al. Hum Reprod Update. 2014;20(4):485-500.

For laboratory research only. Kisspeptin 10 is sold strictly as an in-vitro reference standard. It is not approved for human or veterinary use by Health Canada or the FDA.

$50 CAD