SKU LUM-KP10-1 · C₆₃H₈₃N₁₇O₁₄ · 1302.45 g/mol · CAS 374675-21-5
A C-terminal decapeptide fragment of kisspeptin (KISS1) that activates the GPR54/KISS1R receptor. Investigated for hypothalamic-pituitary-gonadal axis signaling.
Purity (HPLC)
≥ 99.1%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$60CAD/ 10 mg vial
In stock · Lot LM-2740
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years
Overview
Kisspeptin-10 (KP-10) is the minimal C-terminal active fragment of the KISS1 gene product. It binds the G-protein-coupled receptor GPR54 (KISS1R) and stimulates GnRH neurons in the hypothalamus, driving downstream LH and FSH secretion.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our lab.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
YNWNSFGLRF-NH₂
Molecular formula
C₆₃H₈₃N₁₇O₁₄
Molecular weight
1302.45 g/mol
CAS number
374675-21-5
Length
10 residues
Quality
Test
Specification
HPLC purity
99.688%
Mass confirmation
ESI-MS within 0.5 Da
Net peptide content
≥ 80% by AAA
Endotoxin
< 0.5 EU/mg (LAL)
Bioburden
< 10 CFU/g
Residual TFA
< 1.0%
Lot LM-2740
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.17% main peak
ESI-MS (positive)
1302.5 Da (theor. 1302.45)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
de Roux N et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA. 2003;100(19):10972–10976.
Pinilla L et al. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev. 2012;92(3):1235–1316.
Skorupskaite K et al. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485–500.
Kisspeptin 10 is a reproductive endocrine reference standard, classified within the GPR54 signaling pathway. Structurally it is a decapeptide KISS1 fragment. Kisspeptin-10 is the active 10-residue C-terminal fragment of the KISS1 gene product. de Roux et al. (2003) and Seminara et al. (2003) identified its role as the master regulator of GnRH secretion.
In an in-vitro setting, Kisspeptin 10 interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable until reconstituted.
Common research applications
In-vitro receptor-binding and dose-response screens against the GPR54 signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Kisspeptin 10's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.
Storage & handling
Kisspeptin 10 arrives lyophilized in Canada Post (~4 days). On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.
References
de Roux N et al. Proc Natl Acad Sci USA. 2003;100(19):10972-6.
Seminara SB et al. N Engl J Med. 2003;349(17):1614-27.
Skorupskaite K et al. Hum Reprod Update. 2014;20(4):485-500.
For laboratory research only. Kisspeptin 10 is sold strictly as an in-vitro reference standard. Sold as an in-vitro reference standard, not as a Health Canada or FDA-approved therapeutic.
