SKU LUM-GHKCU-50 · C₁₄H₂₄CuN₆O₄ · 403.94 g/mol · CAS 49557-75-7
A naturally-occurring copper-binding tripeptide (Gly-His-Lys) supplied as a 1:1 Cu²⁺ complex. Studied for collagen synthesis, antioxidant activity, and skin-repair pathways.
Purity (HPLC)
≥ 99.42%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$80CAD/ 100 mg vial
In stock · Lot 26-A031
Qty
Add $300 for Free shipping
HPLC + MS verified per lot
~4 days typical to your door
COA bundled with shipment
Lot retains kept 5 years
Overview
GHK-Cu is the copper(II) complex of the tripeptide Gly-His-Lys, originally identified in human plasma. It is investigated for upregulation of collagen and glycosaminoglycan synthesis, antioxidant activity, and modulation of fibroblast and stem-cell behavior in dermal-repair models.
Each vial is lyophilized from a buffered solution, sealed under nitrogen, and shipped ~4 days typical from our lab.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
Identity
Parameter
Value
Sequence
Gly-His-Lys (with Cu²⁺ bound to histidine imidazole + amide nitrogens)
Molecular formula
C₁₄H₂₄CuN₆O₄
Molecular weight
403.94 g/mol
CAS number
49557-75-7
Length
Tripeptide-copper complex
Quality
Test
Specification
HPLC purity
99.969%
Mass confirmation
ESI-MS within 0.5 Da
Net peptide content
≥ 80% by AAA
Endotoxin
< 0.5 EU/mg (LAL)
Bioburden
< 10 CFU/g
Residual TFA
< 1.0%
Lot LM-2771
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Canada. Retain samples held under storage spec for five years from release date.
Verification
Method
Result
RP-HPLC at 220 nm
99.18% main peak
ESI-MS (positive)
403.9 Da (theor. 403.94)
Amino acid analysis
82.1% net peptide
LAL endotoxin
< 0.05 EU/mg
Karl Fischer (water)
2.8% w/w
Reconstitution
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage after reconstitution
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide. Int J Mol Sci. 2018;19(7):1987.
Maquart FX et al. Stimulation of collagen synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. FEBS Lett. 1988;238(2):343–346.
Pickart L et al. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging. Biomed Res Int. 2012;2012:324832.
Shipped in ~4 days typical via Xpresspost from Canada
Background research
What the literature says about Ghk Cu.
Mechanism
Ghk Cu is a copper-binding tripeptide, classified within the wound-repair signaling pathway. Structurally it is a Gly-His-Lys + Cu²⁺ chelation complex. GHK-Cu is a copper-bound tripeptide naturally present in plasma at higher concentrations in young adults than in older ones. Pickart and Margolina (2018) characterized its broad signal-modulating effects on fibroblast proliferation, collagen synthesis, and antioxidant gene expression.
In an in-vitro setting, Ghk Cu interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable until reconstituted.
Common research applications
In-vitro receptor-binding and dose-response screens against the wound-repair signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Ghk Cu's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.
Storage & handling
Ghk Cu arrives lyophilized in Canada Post (~4 days typical). On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.
References
Pickart L, Margolina A. Int J Mol Sci. 2018;19(7):1987.
Maquart FX et al. Connect Tissue Res. 1996;34(3):175-82.
Pickart L et al. BioMed Res Int. 2015;2015:648108.
For laboratory research only. Ghk Cu is sold strictly as an in-vitro reference standard. Sold as an in-vitro reference standard, not as a Health Canada or FDA-approved therapeutic.
